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Discovering enhancer sequences with a role in vertebrate left-right patterning

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If you have a question about this talk, please contact Florian Markowetz .

Left-right (LR) symmetry breaking is a conserved developmental process, and its first morphological manifestation is the looping of the heart in the early vertebrate embryo. Therefore a better understanding of the biology underlying LR-pattering is relevant in the context of congenital heart disease and other cardiomyopathies. On the molecular level, tight spatial and temporal control of gene expression is necessary for proper LR-patterning to occur, and enhancers are cis-regulatory DNA sequences that play essential roles in gene regulation during development. To identify enhancer sequences with a role in LR-patterning, we make use of genome-wide enhancer databases that cover hundreds of tissues and cell types to define “enhancer candidates” based on sequence composition. Next, we use RNA sequencing data do identify LR-differentially expressed genes at the time when heart looping first occurs. Finally, we connect enhancer candidates with target genes, and the most compelling findings will be the input for transgenic follow-up experiments in zebra fish and mouse.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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