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DNMT3A in Hematopoietic Stem Cells, Cancer and Ageing

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  • UserMargaret A. Goodell, Baylor College of Medicine, Houston
  • ClockThursday 18 February 2016, 13:00-14:00
  • HouseCRUK CI Lecture Theatre.

If you have a question about this talk, please contact Kate Davenport .

DNA methyltransferase 3a (DNMT3A) has recently emerged as an important tumor suppressor in hematologic malignancies, and its ablation in mouse hematopoietic stem cells inhibits differentiation. We will describe the use of DNMT3A knockout mice to study its role in myeloid and lymphoid malignancy development and its function in maintaining global DNA methylation. The role of DNMT3A mutations in intercellular competition in the context of ageing will also be discussed.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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