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Using Mouse Models to Understand Metastatic Spread and Tumour Heterogeneity

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  • UserBen Stanger, Perelman School of Medicine, University of Pennsylvania
  • ClockThursday 30 June 2016, 13:00-14:00
  • HouseCRUK CI Lecture Theatre.

If you have a question about this talk, please contact Kate Davenport .

Each cancer is different, harboring unique genetic and epigenetic differences which make it distinct from every other tumour, and even within a given tumour, sub-clones with distinct properties evolve during tumour progression. This inter- and intra-tumoural heterogeneity creates a challenge for understanding tumour biology, since each tumour is a community of cells (containing both cancer and non-cancer cells) rather than a single entity. For several years, we have used mouse models to understand the cellular and molecular events underlying pancreatic cancer, a highly lethal malignancy that is prone to metastasis and resistant to most standard therapies. In particular, we have applied the technique of lineage tracing to understand metastatic progression and tumour-stroma interactions. In the talk, we will describe ongoing efforts using the model to understand both intra- and inter-tumoural heterogeneity in the context of a spontaneously evolving tumour.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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