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Why are tumours dependent on the MYC oncoprotein?

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Description: Cancers arise when cell-signalling pathways, which are normally tightly regulated, become disrupted. Tumours subsequently become dependent on the expression of certain proteins, sometimes referred to as “oncogene addiction”. Identification of these tumour-specific vulnerabilities, absent from normal cells, provides a therapeutic window. In this talk, I provide molecular rationales on how inhibition of the MYC oncoprotein, deregulated in most if not all human cancers, leads to the regression of a multitude of tumour types (including lung, pancreas and mammary).

This talk is part of the Seminars at the Department of Biochemistry series.

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