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Fundamental limits to transcriptional regulatory control

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SDBW03 - Advances in numerical and analytic approaches for the study of non-spatial stochastic dynamical systems in molecular biology

Gene expression is typically regulated by gene regulatory proteins that bind to the DNA . Experiments have shown that these proteins find their DNA target site via a combination of 3D diffusion in the cytoplasm and 1D diffusion along the DNA . This stochastic transport sets a fundamental limit on the precision of gene regulation. We derive this limit analytically and show by particle-based GFRD simulations that our expression is highly accurate under biologically relevant conditions.

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