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Models of Microtubule Acetylation

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SDBW04 - Spatially distributed stochastic dynamical systems in biology

Microtubule (MT) acetylation is done post-translationally in the MT lumen by the acetyltransferase alpha-TAT1. A simple picture is that alpha-TAT1 enters the lumen at the open ends of MT, and diffuses inside while acetylating. Complicating this picture, alpha-TAT1 is approximately half the luminal diameter —- indicating that it may undergo single-file diffusion (SFD). Computationally, we explore the consequences of SFD in this system. Experimentally, in collaboration with the group of Guillaume Montagnac (Institut Gustave Roussy), immunofluorescence techniques allows us to measure the acetylation pattern of individual MT. We try to reconcile the computational and experimental approaches, and highlight open questions. 

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