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Membrane curvature, a non-stochastic regulator of protein localization, structure and function

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If you have a question about this talk, please contact Francesco Simone Ruggeri .

To date we have established exhaustive correlations between the lipid composition of membranes and its impact on membrane properties and protein function. In addition to composition the shape of cellular membranes appears to be a well-conserved phenotype in evolution. Nevertheless we largely ignore what are the consequences of membrane shape/curvature to biological functions that make it so critical for sustaining life. Here I will discuss published and unpublished data from in vitro and living cell experiments on several important classes of biomolecules whose localization, structure or function exhibited dramatic curvature dependence including i) GPC Rs and ii) membrane anchored proteins like Ras.

This talk is part of the Biophysical Seminar series.

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KH107, Keynes House, Cambridge Judge Business School European Bioinformatics Institute Main Lecture Theatre, Divinity School, St John's College, All Saints' Passage St John's College, CB2 1TP

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