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Dr Richard Sandford, Wellcome Trust Senior Fellow in Clinical Research, University Reader in Renal Genetics, Department of Medical Genetics, Cambridge Institute of Medical Research, Addenbrooke's Hospital
Wednesday 06 February 2008, 16:30-17:30
‘Worms, fish, cats and dogs’-Insights in to the pathogenesis of polycystic kidney diseases
- 👤 Speaker: Dr Richard Sandford, Wellcome Trust Senior Fellow in Clinical Research, University Reader in Renal Genetics, Department of Medical Genetics, Cambridge Institute of Medical Research, Addenbrooke's Hospital
- 📅 Date & Time: Wednesday 06 February 2008, 16:30 - 17:30
- 📍 Venue: Lecture Theatre 1, Department of Veterinary Medicine
Abstract
Abstract In man polycystic kidney diseases are a major cause of ill health in adults and children. Genes for many of these diseases, including autosomal dominant polycystic kidney disease (OMIM 173900) and autosomal recessive polycystic kidney disease (OMIM 263200) have recently been identified. Functional characterisation in several different model systems has shown that many cystic kidney disease genes regulate the structure and function of the primary cilium. This structure appears to act as an environmental sensor and the signaling pathways and functions that it regulates are currently being defined. Ciliopathies now form the basis of a new field of molecular, developmental and clinical research.
Series This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.
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