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Dr. Sophie Helaine, MRC Centre for Molecular Bacteriology and Infection, Imperial College London 
Wednesday 31 January 2018, 16:00-17:00
Cancelled - Intracellular Salmonella persisters
- đ¤ Speaker: Dr. Sophie Helaine, MRC Centre for Molecular Bacteriology and Infection, Imperial College London đ Website
- đ Date & Time: Wednesday 31 January 2018, 16:00 - 17:00
- đ Venue: Lecture Theatre 2, Department of Veterinary Medicine
Abstract
Persister bacteria are non-growing, antibiotic insensitive cells, the progeny of which are sensitive to antibiotics. Bacterial persistence is a common phenotype expressed by a large number of bacterial species and is thought to be responsible for relapsing infections. During Salmonella infection of macrophages an important proportion of bacteria enter a persister state via the action of class II toxin-antitoxin modules. These toxin-antitoxin modules encode a stable toxin that inhibits a vital cellular process and a labile, neutralising antitoxin, which is degraded under conditions of stress but otherwise binds and inactivates the toxin. We investigate the activity of three of these toxins, which are acetyltransferases and how bacteria recover from the persistent state.
Series This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.
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