Abstract

“Homeostasis is essential in biological processes and to life itself. To maintain homeostasis receptors and effectors connected in a closed control loop to achieve and maintain equilibrium. Examples include cardiac rhythms, blood glucose regulation, and thermoregulation. Bioelectronic devices are now able to sense and actuate physiological processes by translating biological signals in the form of ions and small molecules into electronic signals that can be analysed and processed by information technologies. I will present our work that merges AI based closed loop control with bioelectronic sensors and actuators to direct physiological processes. I will discuss using fluorescent reporters and ion pumps that can change extracellular ionic concentration to dial membrane potential in stem cells and bacteria colonies. Membrane potential is a key variable that drives cell function and morphogenesis. With this bioelectronic toolbox we can open up opportunities to direct cell fate and organ shape. I will also introduce proof-of-concept applications in wound healing.”