University of Cambridge > Talks.cam > Biochemistry Seminar Series - Internal Speakers > m7G-tRNA in cancer: Molecular mechanism of resistance to METTL1 inhibition

  Browse A-Z

Log in

University Account External (via Google)

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹ️ Information

m7G-tRNA in cancer: Molecular mechanism of resistance to METTL1 inhibition

Download to your calendar using vCal

If you have a question about this talk, please contact .

N7-methylguanosine (m7G) modification of tRNAs is crucial for proper folding and stability of the cellular tRNA pool. It is catalyzed by METTL1 , a methyltransferase overexpressed in a large proportion of malignancies and a promising target for therapeutic purposes. Despite its critical role in cell proliferation, there is a substantial number of cancers insensitive to METTL1 inhibition and its genetic abrogation. Helena will present her progress towards the characterization of molecular pathways underlaying METTL1 resistance in human cancer cells.

This talk is part of the Biochemistry Seminar Series - Internal Speakers series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Average on weekdays: 9224.3627907 kWh Centre for Advanced Photonics and Electronics, 9, JJ Thompson Ave. test

Other talks

Rothschild Public Lecture: The Quantum Centenary: from Order to Chaos Topic Film, TV shows for Medical Education, ‘The Wire’ as a case study TBC Sera Markoff Inaugural Lecture for the Plumian Professorship in Astronomy and Experimental Philosophy - 'Staring into the heart of darkness: from theory to the direct imaging of black holes' LMB Seminar - Mechanisms of mRNA packaging and export Group Work
 

© 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity