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Mitochondrial Reactive Oxygen Species: Signals or Stresses?

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If you have a question about this talk, please contact Penny Peck .

Mitochondria have been known to generate reactive oxygen species (ROS) for nearly fify years. Initially viewed as toxic byproducts of the electron transport chain, these oxidants have been implicated in a wide range of human diseases. However, most clinical trials of antioxidant therapies have failed to attenuate disease progression or pathogenesis. More recent studies reveal that spatial organization of ROS generation occurs in healthy and diseased cells, and that some mitochondrial ROS play important roles in signaling cell stress and activating protective responses. This talk will examine these disparate roles for mitochondrial ROS , and describe new approaches to assessing intracellular oxidant stresses in health and disease.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

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