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Microglia: Special Award for Best Supporting Actor

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If you have a question about this talk, please contact Shannon Tinley-Browne .

Microglia are the resident macrophages of the brain and provide a surveillance and scavenging function. However, although microglia have been shown to engulf and clear damaged cellular debris after brain insult, it remains less clear what role these cells play in the uninjured brain. New evidence show that microglia actively engulf synaptic material and play a major role in synaptic pruning during postnatal development in mice. These findings support a crucial role for microglia in synaptic and neural circuit maturation and suggest that deficits in their function may contribute to synaptic abnormalities seen in some neurodevelopmental disorders.

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