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Cutting as Untying (Topo2: Resolving the Gordian Knot of the Cell since 3.8 billion B.C.)

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If you have a question about this talk, please contact Aleksandr Sahakyan .

Topoisomerases are a highly conserved family of enzymes found in Archaea, mammals and everything in between. They are the enzymes responsible for relieving super- and under-coiled DNA and are thus a necessary component of every self-contained organism with nucleic acids.

Our work focuses on how human topoisomerase (topo) 2Îą is regulated in the cell. Particularly, we are studying how SUMO modifications affect topo 2Îą activity and localisation through the cell cycle.

This talk is part of the Darwin College Science Seminars series.

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