University of Cambridge > Talks.cam > Biophysical Seminars > Rational design of protein aggregation

  Browse A-Z

Log in

Googledetails Microsoftdetails

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹī¸ Information

Rational design of protein aggregation

Download to your calendar using vCal

If you have a question about this talk, please contact Jerome Charmet .

Protein aggregation is in large part determined by the presence of aggregation-prone segments in a protein sequence and their relation with the native structure. During this presentation I will illustrate how these aggregation-determining sequences can be engineered to increase aggregation resistance without affecting native protein structure. I will also show how these sequences can be harnessed to induce specific aggregation-induced loss-of-function phenotypes in bacteria, plants and mammalian cells. Both inhibiting and inducing aggregation could lead to useful biotechnological application. These exercises also inform on the evolutionary options allowing folded proteins to adapt solubility and on the sequence-dependence of protein aggregate toxicity.

This talk is part of the Biophysical Seminars series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Taking Place: Affective Urban Geographies Postgraduate Travel Group Institute of Metabolic Science (IMS), Level 4 ATC, Seminar rooms 1,2 & 3

Other talks

Title TBC Online Causal Inference Seminar Title to be confirmed Title TBC Coming soon Tissue-scale communication in cancer development
 

Š 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity