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Directing and shaping the inside-out axis of the vertebrate brain

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If you have a question about this talk, please contact Caroline Newnham .

Host: Ben Steventon

We are attempting to understand the developmental mechanisms that drive organ and cell morphogenesis in the vertebrate embryo central nervous system. The fundamental building block of the embryonic vertebrate brain is the neural tube which is an epithelium composed of apicobasally polarized neural progenitors. The polarity of these cells is essential for many of the key events in building a brain but how this polarity is established is poorly understood. We use the accessibility and transparency of the zebrafish embryo to better understand neuroepithelial polarity and morphogenesis, and we are currently focused on the role of cell division-dependent and division-independent processes, directional signals from the ECM and the potential role of biomechanical forces.

This talk is part of the Genetics Seminar series.

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