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Nazma Malik.
Wednesday 12 July 2023, 12:30-13:30
Immunology in Pathology
A seminar series organised from the Division of Immunology in the Department of Pathology, supported in part by the British Society for Immunology (BSI) through the Cambridge Regional Group. The seminars are in the Pathology Building on the Downing site (fronting on Tennis Court Road) from 12:30-1:30 on Wednesdays during term time.
Contact: Phil Brereton
0 upcoming talks View 335 archived talks
Investigating thymic Treg selection and death by a transcriptional timer and single cell methods.
β οΈ Host: Rahul Roychoudhuri, rr257@cam.ac.uk
Uncertainties around SARS-CoV-2 infection and immunity.
β οΈ Host: Nick Holmes, nh106@cam.ac.uk
Principles of squamocolumnar transition zone homeostasis: metaplasia, infections, and cancers.
β οΈ Host: Margherita Turco, myt25@cam.ac.uk
The Marginal Zone B cell - T follicular helper cell connection.
β οΈ Host: Klaus Okkenhaug, ko256@cam.ac.uk
Isolation and analysis of Immune niches along the human intestine.
β οΈ Host: Klaus Okkenhaug (ko256@cam.ac.uk), tea and coffee available at 12.15
Protection against pathogen colonisation and transmission by the microbiota.
β οΈ Host: Klaus Okkenhaug (ko256@cam.ac.uk), tea and coffee available at 12.15
Oxygen-dependent control of T-cell mediated immunity.
β οΈ Host: Nick Holmes, (nh106@cam.ac.uk), tea and coffee available at 12.15
Mechanisms of germinal centre dependent antibody dysregulation in early life.
β οΈ Host: Naomi McGovern, nm390@cam.ac.uk; Tea and coffee will be available at 12.15
Candida recognition and manipulation of NK cells.
β οΈ Host: Dr Francesco Colucci (fc287@medschl.cam.ac.uk)
Adaptive control of RIPK1 dependent cell death signalling in T-cells.
β οΈ Tea and coffee will be available at 12.15
Molecular approaches for studying antigen processing topology and T-cell activation kinetics.
β οΈ Host: Louise Boyle (lhb22@cam.ac.uk), tea and coffee available at 12.15pm
Epitope target discovery: what can we see when we think outside the box.
β οΈ Host: Louise Boyle (lhb22@cam.ac.uk), tea and coffee available at 12.15pm
Integrative NMR, Molecular Modeling, and Functional studies of immune recognition complexes
β οΈ Host: Louise Boyle (lhb22@cam.ac.uk), tea and coffee available at 12.15pm
Meticulous and Multifaceted: How herpes viruses fine tune the innate immune response.
β οΈ Host: Brian Ferguson (bf234@cam.ac.uk)
Immune cell recognition on a nanoscale.
β οΈ Host: Louise Boyle (lhb22@cam.ac.uk)
HLA-E Revisited
β οΈ Host: John Trowsdale (Jt233@cam.ac.uk)
Understanding hepatic macrophage heterogeneity and function in NAFLD
β οΈ Host: Naomi McGovern (nm390@cam.ac.uk)
CD8 T cell surveillance of lymphoid and non-lymphoid tissues.
β οΈ Host: Klaus Okkenhaug (ko256@cam.ac.uk)
How do macrophages respond to danger?
β οΈ Host: Naomi McGovern, nm390@cam.ac.uk; Tea and coffee will be available at 12.15
Reining in T follicular helper cells in humoral immunity and T cell lymphoma
β οΈ Hosted by: Klaus Okkenhaug. There will be tea and coffee available at 12.15.
Integrating T cell Signals
β οΈ Note unusual time, (Tuesday 1230) (12.15 Refreshments available)
From SNPs to biology in autoimmune disease
β οΈ Host: James Traherne (jat51@cam.ac.uk)
Intracellular trafficking for immunity
β οΈ Host: Brian Ferguson (bf234@cam.ac.uk)
Uterine immunity one cell at a time
β οΈ Host: Dr Bidesh Mahata (bm11@sanger.ac.uk)
βIn vivo tracking of immune cell migration: towards a better understanding of tumour infiltrating lymphocytesβ
β οΈ Host: Dr Bidesh Mahata (bm11@sanger.ac.uk)
Adaptive immunity in wild songbirds
β οΈ Host: Professor Jim Kaufman (jfk31@cam.ac.uk)
Antigen receptor repertoires and specificities at single-cell resolution
β οΈ Host: Dr Bidesh Mahata (bm11@sanger.ac.uk)
Regulators of chicken B cell development β basic research and application
β οΈ Host: Professor Jim Kaufman (jfk31@cam.ac.uk)
Fish 'n' HIFs: Hypoxia signalling in zebrafish models of infection and inflammation
β οΈ Host: Dr Naomi McGovern (nm390@cam.ac.uk)
Immune regulatory functions of group 2 innate lymphoid cells
β οΈ Host: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
Niche dependencies for normal and malignant B1 cells
β οΈ Host: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
Organoid Systems to Study the Maternal-Fetal Interface of Human Pregnancy
β οΈ Host: Dr Naomi McGovern (nm390@cam.ac.uk)
Beyond the cancer cell: Exploring the tumour stroma as immune modulators
β οΈ Host: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
Engineering the genetic events of lymphomagenesis in normal human germinal centre B-cells
β οΈ Host: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
CANCELLED
β οΈ Canceled
Darwin's digital moth: predicting the existence of new components of immune systems by evaluating convergent patterns of nucleotide motif usage in viruses and their hosts
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
Mitochondria as inflammatory killers
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
T cell intrinsic role of Arginase 2 in modulating anti-tumor immunity
β οΈ Host: Professor Jim Kaufman (jfk31@cam.ac.uk)
Host MHC and genomic diversity retards experimental evolution of viral virulence
β οΈ Host: Professor Jim Kaufman (jfk31@cam.ac.uk)
Understanding human innate immune memory
β οΈ Host: Dr Naomi McGovern (nm390@cam.ac.uk)
Monocyte kinetics and functions in health and disease
β οΈ Host: Dr Naomi McGovern (nm390@cam.ac.uk)
New insights into how Butyrophilin(-like) proteins shape gammadelta T cell repertoires
β οΈ Host: Professor Jim Kaufman (jfk31@cam.ac.uk)
Tracking hematopoietic clonal life histories in the rhesus macaque model
β οΈ Host: Dr Andrew Sharkey (as168@cam.ac.uk)
Global outbreaks: interferons as first responders
β οΈ Host: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
Challenges in human respiratory viral infection
β οΈ Host: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
Adaptive immunesurveillance by human Ξ³Ξ΄ T cells
β οΈ Host: Dr David Rhodes (dar32@cam.ac.uk)
Regulation of resistance and tolerance at the intestinal barrier
β οΈ Host: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
Red Queen drives selection on MHC genes
β οΈ Host: Professor Jim Kaufman(jfk31@cam.ac.uk)
A novel aspect of Macrophage biology: learning from the great opportunist HIV-1
β οΈ Host: Dr Naomi McGovern (nm390@cam.ac.uk)
Novel kinases controlling T cell development, trafficking and immune responses
β οΈ Host: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
Type I IFN induces CXCL13-driven B cell recruitment to the lung to enable tertiary GC formation
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
Characterizing Immunogenetic Mechanisms through HIV Disease Analysis
β οΈ Host: Dr James Traherne (jat51@cam.ac.uk)
Metabolic regulation of T cell trafficking
β οΈ Host: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
NK cells: in and out of the circulation
β οΈ Host: Dr Andrew Sharkey (as168@cam.ac.uk)
'Gene regulation in the innate and adaptive immune systems'
β οΈ Host: Dr Nick Holmes (nh106@cam.ac.uk)
A sex-linked supergene controls sperm morphology and swimming speed in a songbird
β οΈ Host: Professor Jim Kaufman (jfk31@cam.ac.uk)
How T-cells cause autoimmune disease and hold the key to curing cancer
β οΈ Host: Professor Jim Kaufman (jfk31@cam.ac.uk)
Phenotypic model explains adaptation of T cell responses to antigen by TCR downregulation
β οΈ Host: Dr Nick Holmes (nh106@cam.ac.uk)
Diversity of the human response to malaria
β οΈ Host: Dr Maja WΓ₯llberg (mw394@cam.ac.uk)
Metabolic adaptation as a disease tolerance mechanism against infection
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
Immunity in early life: the case of gammadelta T cells
β οΈ Host: Dr David Rhodes (dar32@cam.ac.uk)
Stromal microenvironments and the control T-cell development and selection
β οΈ Host: Dr Nick Holmes (nh106@cam.ac.uk)
Glucose inhibits Dendritic cell-induced CD8 T cell responses
β οΈ Host: Dr Maja Wallberg (mw394@cam.ac.uk)
Genetic analyses of ANCA-associated vasculitis inform diagnostic and therapeutic strategies.
β οΈ Host: Dr James Traherne (jat51@cam.ac.uk)
Dendritic cells and antigen export into the cytosol for cross-presentation
β οΈ Host: Dr Louise Boyle (lhb22@cam.ac.uk
Exploring the functions of monocyte subsets
β οΈ Host: Dr Naomi McGovern (nm390@cam.ac.uk)
Death receptors and ubiquitin in cell death, inflammation and immunity
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
Immunorecognition and disease therapy
β οΈ Host: Prof Jim Kaufman (jfk31@cam.ac.uk)
Dr David Tscharke: Vaccinia virus presents: A proteome-wide view of antigen presentation during virus infection
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
Prof Robyn Slattery: The Songlines between Scientific and Social Silos: A nomadic approach to Immunology teaching, learning and research
β οΈ Host: Dr Nick Holmes (nh106@cam.ac.uk)
Dr Maike de la Roche: Hedgehog Signalling in T cells
β οΈ Host: Dr Louise Boyle (lhb22@cam.ac.uk)
Dr Sarah Teichmann: Understanding Cellular Heterogeneity
β οΈ Host: Dr Nick Holmes (nh106@cam.ac.uk)
Dr Tony Jackson: Protein neighbours and proximity proteomics
β οΈ Host: Prof Jim Kaufman (jfk31@cam.ac.uk)
Professor Alain Vanderplasschen: Conserved fever pathways across vertebrates: a herpesvirus delays fish behavioural fever through expression of a decoy TnfΞ± receptor
β οΈ Host: Prof Jim Kaufman (jfk31@cam.ac.uk)
Dr David Komander: Studying non-existent ubiquitin chains
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
Prof Jan Rehwinkel: Nucleic Acid Sensing by Innate Immune Receptors
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
Dr Amir Horowitz: Harnessing NK cell functions for treatments against viruses and cancers
β οΈ Host: Dr Andrew Starkey
Prof Serge Muyldermans: Nanobodies, a versatile tool for multiple applications
β οΈ Host: Lisa Kent (lsk29@cam.ac.uk)
Prof Benedikt Kaufer: Herpesvirus latency: From neuronal models to integration into host telomeres
β οΈ Host: Prof Jim Kaufman (jfk31@cam.ac.uk)
Dr Serge Mostowy: New roles for the cytoskeleton in cell-autonomous immunity
β οΈ Host: Dr Francesco Colucci (fc287@medschl.cam.ac.uk)
Prof Steve Renshaw: Will zebrafish help lead a revolution in inflammation biology?
β οΈ Host: Dr Milka Sarris (ms543@cam.ac.uk)
Prof Peter Parham: Resurrecting an Intermediate in the Evolution of Human HLA-C specific NK Cell Receptors
β οΈ Host: Prof Jim Kaufman (jfk31@cam.ac.uk)
Dr Neil McCarthy: Human VΞ΄2+ T-cells in Intestinal Inflammation
β οΈ Host: Dr David Rhodes (dar32@cam.ac.uk)
Dr Leonie Unterholzner: Sensing intracellular DNA as "stranger" and "danger" signal
β οΈ Host: Ben Trigg (bjt40@cam.ac.uk)
Dr Frank Waldron-Lynch: Immune Cell Responses in Participants with Type 1 Diabetes after doses of Interleukin-2 in adaptive-response clinical trials
β οΈ Host: Dr Louise Boyle (lhb22@cam.ac.uk)
Prof Anthony Purcell: New insights into antigen presentation using quantitative immunopeptidomics
β οΈ Host: Dr Louise Boyle (lhb22@cam.ac.uk)
Dr Oliver Bannard: Germinal centres; regulation by position and program
β οΈ Host: Dr Nick Holmes (nh106@cam.ac.uk)
Dr Peter van Endert: Intracellular trafficking events regulating MHC class I antigen cross-presentation by dendritic cells
β οΈ Host: Dr Louise Boyle (lhb22@cam.ac.uk)
Dr David Bending: A novel tool to visualize and manipulate the dynamics of T cell regulation in vivo
β οΈ Host: Dr Nick Holmes (nh106@cam.ac.uk)
Dr Megan MacLeod: Regulation of CD4 T cell retention and function at inflamed sites
β οΈ Host: Dr Maja Wallberg (mw394@cam.ac.uk)
Professor Geoffrey L Smith: Modulation of CD8+ T cell and NK cell memory by vaccinia virus
β οΈ Host: Dr Nick Holmes (nh106@cam.ac.uk)
Dr Pavel Tolar: The biomechanics of B cell activation
β οΈ Host: Dr Nick Holmes (nh106@cam.ac.uk)
Dr Peter Bull: Exploring host selection pressures on malaria parasite populations during human infection
β οΈ Host: Dr Nick Holmes (nh106@cam.ac.uk)
Dr Anja Schmidt-Christensen: Dissecting inflammation in diabetes
β οΈ Host: Dr Maja Wallberg (mw394@cam.ac.uk)
Dr Peter Bull:
β οΈ Host: Dr Nick Holmes (nh106@cam.ac.uk)
Prof Wilf Jefferies: Weft, Warp & Weave: The intricate tapestry of antigen processing pathways controlling T lymphocyte function
β οΈ Host: Prof John Trowsdale (jt233@cam.ac.uk)
Prof Thomas Herrmann: Control of Vgamma9Vdelta T cell activation by butyrophilin 3 and their possible coevolution
β οΈ Host: Dr David Rhodes (dar32@cam.ac.uk)
Dr Duncan Howie: T cell metabolism and immune tolerance
β οΈ Host: Dr Maja Wallberg (mw394@cam.ac.uk)
Dr Jodie Goodridge: Natural Killer Potential
β οΈ Host: Prof John Trowsdale (jt233@cam.ac.uk)
Dr Francois Legoux: CD4+ T cell tolerance to self-antigens
β οΈ Host: Dr Maja Wallberg (mw394@cam.ac.uk)
Prof Paul Bowness: Type 17 immune responses in Ankylosing Spondylitis
β οΈ Host: Dr Louise Boyle (lhb22@cam.ac.uk)
Dr Michael Weekes: New insights into human cytomegalovirus immune evasion from quantitative multiplexed proteomics
β οΈ Host: Dr Louise Boyle (lhb22@cam.ac.uk)
Prof Connie Trimble: HPV therapeutic vaccines β where are we now and where are we going?
β οΈ Host: Prof Margaret Stanley (mas1001@cam.ac.uk)
Dr Pia Kvistborg: What T cells see on human cancer
β οΈ Host: Dr Louise Boyle (lhb22@cam.ac.uk)
Dr Antonio Rothfuchs: Dendritic cell migration and T-cell priming to Bacille Calmette-GuΓ©rin
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
Dr Jatin Vyas: Dectin-1 and innate immunity against fungal pathogens
β οΈ Host: Dr Katerina Artavanis-Tsakonas (ka447@cam.ac.uk)
Dr Piero Mastroeni: Immunity and vaccination to invasive Salmonella infections: How can we integrate the lessons from animal models and man?
β οΈ Host: Prof Jim Kaufman (jfk31@cam.ac.uk)
Dr Jane Goodall: How can I modify dendritic cell biology? A lesson from TSLP
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
Prof Philip Goulder: Non-progressing paediatric HIV infection
β οΈ Host: Dr Louise Boyle (lhb22@cam.ac.uk)
Prof Lutz Walter: Immunogenetics of the rhesus macaque SIV infection model
β οΈ Host: Prof Jim Kaufman (jfk31@cam.ac.uk)
Dr Marion Espeli: New mechanisms of regulation of germinal centre B cells and plasma cells
β οΈ Host: Dr Maja Wallberg (mw394@cam.ac.uk)
Dr Ian Humphreys: Immune Regulation during Cytomegalovirus Infection: Walking a Fine Line
β οΈ Host: Dr Louise Boyle (lhb22@cam.ac.uk)
Prof Jim Kaufman: A gut feeling about MHC class II molecules
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
Dr Nicola Ternette: Definition of the origin and nature of HLA class I-associated peptide presentation from HIV-1 using mass spectrometry.
β οΈ Host: Prof Jim Kaufman (jfk31@cam.ac.uk)
Dr Klaus Okkenhaug: PI3K in infection, immunity and cancer.
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
Dr Eoin McKinney: Sometimes better off sick and tired - T cell exhaustion and outcome in autoimmunity and infection.
β οΈ Host: Dr Louise Boyle (lhb22@cam.ac.uk)
Dr Emmanuel Donnadieu: Decoding T cell responses to cancer with dynamic imaging
β οΈ Host: Prof John Trowsdale (jt233@cam.ac.uk)
Dr Edd James: Immune Dysfunction: the role of polymorphic ERAP1 in disease.
β οΈ Host: Dr Louise Boyle (lhb22@cam.ac.uk)
Dr Yongliang Zhang: MKP5, a novel regulator of IRF3-type I IFNs, critically modulates host-pathogen interaction in influenza and other RNA virus infections.
β οΈ Host: Prof John Trowsdale (jt233@cam.ac.uk)
Dr Naomi McGovern: Human dendritic cells β from adult to fetus.
β οΈ Host: Dr Francesco Colucci (fc287@medschl.cam.ac.uk)
Generators of diversity and the host-pathogen interface
β οΈ Dr Nina Papavasiliou, The Rockefeller Institute, New York
Trophoblast-microbiota interaction: a new paradigm on immune regulation during pregnancy
β οΈ Host: Francesco Colucci (fc287@medschl.cam.ac.uk)
Navigating through tissue mazes: how leukocytes find their way to sites of infectionβ
β οΈ Host: Brian Ferguson (bf234@cam.ac.uk)
MHC class I : From viral evasion to cellular quality control?
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
A novel gene essential for the generation of reactive oxygen species and host defence
β οΈ Host: Nick Holmes (nh106@cam.ac.uk)
Decoding immune responses to cancer and infection using intravital imaging
β οΈ Host: Milka Sarris (ms543@cam.ac.uk)
Tuberculous Granuloma Formation and Function
β οΈ Host: Brian Ferguson (bf234@cam.ac.uk)
Studying CD4+ T cell interactions with dendritic cells in vivo
β οΈ Host: Maja Wallberg (mw394@cam.ac.uk)
New Pathophysiological Roles of Atypical Chemokine Receptors
β οΈ Host: Dr Milka Sarris (ms543@cam.ac.uk)
Intracellular DNA recognition by the innate immune system
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
How protein plasticity influences MHC class I peptide selection: insights into mechanism
β οΈ Host: Professor Jim Kaufman (jfk31@cam.ac.uk)
Group 2 Innate Lymphoid Cells regulate the innate and adaptive immune response to inhaled allergens
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
Bacterial autophagy and the cytoskeleton in host defence
β οΈ Host: Dr Milka Sarris (ms543@cam.ac.uk)
Human Cytomegalovirus the paradox of immune evasion and control
β οΈ Host: Professor John Trowsdale (jt233@cam.ac.uk)
Regulation of T cell homeostasis by tyrosine phosphatase PTPN22
β οΈ Host: Dr Nick Holmes (nh106@cam.ac.uk)
Responses of mesenchymal stromal cells to hypoxia
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
The impact of metabolism on NK cell immune functions
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
Innate immune cell memory
β οΈ Host: Brian Ferguson (bf234@cam.ac.uk)
Autophagy in host-pathogen interactions
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
The IL-6 cytokine family and CD4+ T cell response during acute and chronic viral infections
β οΈ Host: Chris Rudd (cer51@cam.ac.uk)
Myeloid lineage switch in pro-B cells generates novel M phi subsets during homeostasis & inflammation
β οΈ Host: Paola Zaccone (pz206@cam.ac.uk)
CANCELLED
β οΈ Host: Brian Ferguson (bf234@cam.ac.uk)
Positive and Negative Selection in Avian B Cell Development
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
An inverse correlation of cell surface expression level and peptide binding repertoire for MHC class I molecules is associated with disease resistance in chickens and humans
β οΈ Host: Brian Ferguson (bf234@cam.ac.uk)
Regulation of virally-induced lung inflammation by interferons
β οΈ Host: Brian Ferguson (bf234@cam.ac.uk)
Sensing and signalling in innate immunity: Role of PYHIN proteins
β οΈ Host: Brian Ferguson (bf234@cam.ac.uk)
C-type lectins in homeostasis and immunity
β οΈ Host: Paola Zaccone (pz206@cam.ac.uk)
Killer T Cells: staying on target
β οΈ Host: Ashley Moffett (am485@cam.ac.uk)
Using genomics to refine diagnosis and prognosis in ANCA-associated vasculitis
β οΈ Host: Professor John Trowsdale (jt233@cam.ac.uk)
Ex-FoxP3 Regulatory T cells uniquely populate the inflamed site in childhood arthritis
β οΈ Host: Nick Holmes (nh106@cam.ac.uk)
Pattern Recognition Receptors and Infection: Following the Speck
β οΈ Host: Brian Ferguson (bf234@cam.ac.uk)
Targeting Immune Checkpoints in Cancer: New Mechanistic Insights
β οΈ Host: Chris Rudd, cer51@cam.ac.uk
Inhibition of HIV-1-cofactor interactions triggers innate sensors and interferon secretion
β οΈ Host: Brian Ferguson, bf234@cam.ac.uk
Exploring the mechanisms of immunity operating against a protist parasite of the gut
β οΈ Host: Ben Trigg, bjt40@cam.ac.uk
Trafficking of MHC class I molecules is influenced by so many things - lessons from a new peptide-independent mutant
β οΈ Host: Dr Louise Boyle, lhb22@cam.ac.uk
How hepatitis B virus exploits the immune environment in the liver
β οΈ Host: Ashley Moffett, am485@cam.ac.uk
The unicity of diversity: cross-allele T-cell responses against viruses and tumors among different HLA-A supertypes and the structural bases
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
Immune-mediated sperm selection
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
Apoptosis, Necrosis, Atherosclerosis and IL-1
β οΈ Host: John Trowsdale, jt233@cam.ac.uk
The double life of killer cells: NK in reproduction and cancer
β οΈ Host: John Trowsdale, jt233@cam.ac.uk
Host-pathogen interactions in the chicken - from molecules to mapping
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Migration in Development and Immune Function: the Role of alpha4 integrin (CD49d, VLA-4)
β οΈ Host: Dr Nick Holmes (nh106@cam.ac.uk)
New insight into the mechanism controlling peptide selection by MHC class I
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
Transancestral Fine mapping of Susceptibility Loci in SLE
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
Reproduction, infection and KIR evolution: a modelling approach
β οΈ Host: Professor Ashley Moffett (am485@cam.ac.uk)
Shooting the messenger - Unique cytotoxic strategy in recently activated CD8 T cells
β οΈ Host: Professor Chris Rudd (cer51@cam.ac.uk)
Studies on pathogen-macrophage interactions: a possible role for a secreted Mycobacterium tuberculosis lectin
β οΈ Host: Dr Brian Ferguson (bf234@cam.ac.uk)
Influenza Adrift: Rethinking Influenza A Virus Evolution
β οΈ Host: Dr Adrian Kelly (apk23@cam.ac.uk)
Viral inhibition of DNA-PK dependent DNA sensing
β οΈ Host: Professor Jim Kaufman (jfk31@cam.ac.uk)
A View to a Kill - Natural killer cell recognition of classical, non classical and virus-encoded MHC-like molecules
β οΈ Host: Professor Ashley Moffett (am485@cam.ac.uk)
Conservation of Binding by Leukocyte Receptor Complex family members to Class I Antigen Presenting Molecules: Why does KIR3DL1 bind Mouse H-2Db?
β οΈ Host: Professor Ashley Moffett (am485@cam.ac.uk)
Ecology, evolution and ecosystem consequences of a novel infectious cancer: Tasmanian devil facial tumour disease
β οΈ Host: Professor Jim Kaufman (jfk31@cam.ac.uk)
Influence of HLA-C expression level on HIV control
β οΈ Host: Ashley Moffett (am485@cam.ac.uk)
Macrophage heterogeneity and renewal during inflammation
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
Mothers' compromise. How NK cells regulate placentation.
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Immunomodulation of Type 1 Diabetes by Schistosome mansoni products
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Recombinant HPA-1a antibody therapy for treatment of fetomaternal alloimmune thrombocytopenia
β οΈ Host: Mike Clark (mrc7@cam.ac.uk)
Burning bridges. Transgenic approaches to eliminate the intermediate hosts of pandemic influenza.
β οΈ Host: Adrian Kelly (apk23@cam.ac.uk)
Foxp3, TSLP, and the regulation of immunity and inflammation
β οΈ Host: John Rogers, PDN (jhr11@cam.ac.uk)
Innate crosstalk of unconventional T cells, monocytes and neutrophils in bacterial infection
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
Direct Nuclear Pore Complex Regulation of T-cell Induced Inflammation
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Immune profiling the human NK cell repertoire using mass cytometry (CyTOF)
β οΈ Host: Ashley Moffett (am485@cam.ac.uk)
The role of KIR3DL2 HLA-B27 interactions in inflammatory arthritis - symptom or cause?
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
Preclinical and clinical studies of immunotherapy in type 1 diabetes
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
Influence of the microbiota on immune system homeostasis
β οΈ Host: Chris Rudd (cer51@cam.ac.uk)
Recognition of herpesviruses by the innate immune system
β οΈ Host: Brian Ferguson (bf234@cam.ac.uk)
'Dendritic cells and pluripotency: Unlikely allies in the pursuit of immunotherapy'
β οΈ Host: Nick Holmes (nh106@cam.ac.uk)
The evolution of Natural Killer cell receptors: alternative strategies to recognise self and create immune variation
β οΈ Host: Hannah Siddle (hvs26@cam.ac.uk)
Defining a role for Natural Killer cells in HCV infection
β οΈ Host: Ashley Moffett (am485@cam.ac.uk)
IRF5 in regulation of macrophage inflammatory gene programme
β οΈ Host: Chris Rudd (cer51@cam.ac.uk)
Defense, counter defense and counter counter defense in host pathogen interactions of plants
β οΈ Host: Brian Ferguson (bf234@cam.ac.uk)
Lesson from the skin: the Aryl hydrocarbon Receptor (AhR) as an inflammatory brake in psoriasis
β οΈ Host: Anne Cooke (ac@mole.bio.cam.ac.uk)
Using super-resolution microscopy to watch immune cells kill
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
Hepcidin, immunity and global health
β οΈ Host: Adrian Kelly (apk23@cam.ac.uk)
Toll and TLR function in inflammation and neurogenesis
β οΈ Host: Adrian Kelly (apk23@cam.ac.uk)
Induction of broadly neutralising antibodies against HIV in Llamas
β οΈ Host: Brian Ferguson (bf234@cam.ac.uk)
The importance of MHC protein dynamics for antigen presenting function
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
LAT signalling pathology: a T-cell dependent, B cell autoimmune condition without T cell self-reactivity
β οΈ Host: Chris Rudd (cer51@cam.ac.uk)
Insights into regulatory genetic variation involving the human MHC
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
TLR3-IFN deficiencies underlying Herpes simplex encephalitis
β οΈ Host: Brian Ferguson (bf234@cam.ac.uk)
Novel targets to treat hyper-immune syndromes revealed by physiologic responses to DNA nanoparticles
β οΈ Host: Anne Cooke (ac@mole.bio.cam.ac.uk)
Selection of IgG properties for therapeutic applications
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
The existence of species rests on a metastable equilibrium between inbreeding and outbreeding. Trying to explain why Darwin could not solve the mystery of mysteries.
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Nrp-1: Sticky memories?
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
Insights into human papillomavirus persistence and cervical carcinogenesis from the W12 model system
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Phylogenetic origin of the vertebrate leukocyte receptors
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
A quantitative view of gene expression levels in the T helper cell system
β οΈ Host: Nick Holmes (nh106@cam.ac.uk)
MHC haplotyping in rhesus and cynomolgus macaques
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
Elucidating the relative roles of the TCR and CD8 co-receptor in T cell recognition of peptide-MHCI
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Autoreactive CD4 T Cells and their Antigens in Type 1 Diabetes
β οΈ Host: Anne Cooke (ac@mole.bio.cam.ac.uk)
Surprise, surprise! The molecular evolutionary immunoecology of the ubiquitous protozoal pathogen, Toxoplasma gondii
β οΈ Host: John Trowsdale, jt233@cam.ac.uk
Memory CD4 T cell generation and survival within secondary lymphoid tissue
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
The Aryl Hydrocarbon Receptor: an interpreter of the micro-environment
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
NK cells: turning off the off switch
β οΈ Host: Ashley Moffett, am485@cam.ac.uk
Lessons from pathogens - identifying novel cell surface receptors targeted by viruses
β οΈ Host: Adrian Kelly, apk23@cam.ac.uk
Natural Killers or Natural Protectors? The Role of NK cells During Intestinal Inflammation
β οΈ Host: Dr Francesco Colucci, fc287@medschl.cam.ac.uk
Human NK cell activation and inhibition in vivo
β οΈ Host: John Trowsdale, jt233@cam.ac.uk
The chicken leukocyte receptor cluster
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
Are mammary epithelial cells specialised immune cells?
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
Origin and Transformation of T Cell Progenitors
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
Protective immunity in HIV infection? A tale of two villages
β οΈ Host: Ashley Moffett, am485@cam.ac.uk
Positive and negative influences of regulatory T cells in generating the naΓ―ve T cell compartment
β οΈ Host: Nick Holmes, nh106@cam.ac.uk
A genome-wide consideration of genes controlling MHC class II function and beyond
β οΈ Host: John Trowsdale, jt233@cam.ac.uk
Dissecting signals of genetic association to complex diseases within the HLA
β οΈ Host: John Trowsdale, jt233@cam.ac.uk
Membrane rafts in immunoreceptor signaling - reality vs. artefacts
β οΈ Host: Helga Schneider, hs383@cam.ac.uk
What have we learnt about the evolution of the cytokine network from studies in fish?
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
Endosomal Feedback at the T-cell Immune Synapse
β οΈ Host: Chris Rudd, cer51@cam.ac.uk
Understanding copy number variation in human antimicrobial defensin genes
β οΈ Host: John Trowsdale, jt233@cam.ac.uk
Modulation of innate immunity by vaccinia virus
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
HIV-1 spread between immune cells
β οΈ Host: Peter Goon, pg336@cam.ac.uk
Stat3: The Secret Ingredient to turn Lysosomes deadly?
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
Mechanisms of immune regulation by CTLA-4: Immunology meets cell biology
β οΈ Host: John Trowsdale, jt233@cam.ac.uk
Imaging Immune Responses In Vivo
β οΈ Host: Chris Rudd, cer51@cam.ac.uk
Macrophage paired receptors - structure, interactions and evolution
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
How cells defend their cytosol against bacterial invasion
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
Bacterial interference in MHC class II antigen processing
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
MHC and disease: a novel hypothesis
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
What constitutes a protective HLA class I molecule, and why doesn't it always work?
β οΈ Host: Peter Goon, pg336@cam.ac.uk
What are B cells good for?
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
Using our WITS to explore fine structure dynamics of Salmonella and Campylobacter infections
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
Crosstalk between TLR and Stress pathways: relevance to IL-23 expression
β οΈ Host: John Trowsdale, jt233@cam.ac.uk
'Pathogenic', 'Protective' and 'Plastic': So what is a Th17 cell?
β οΈ Host: Anne Cooke (ac@mole.bio.cam.ac.uk)
A selective sweep in chimpanzees: Is SIV the culprit?
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
Probing lymphocyte activation using single chain MHC class I molecules
β οΈ Host: Peter Goon, pg336@cam.ac.uk
How pathogens reprogram their host: re-wiring of hematopoietic development during acute infection
β οΈ Host: Anne Cooke, ac@mole.bio.cam.ac.uk
BG: a rapidly evolving family of cell surface proteins
β οΈ Jim Kaufman, jfk31@cam.ac.uk
Unraveling the long-term evolutionary history of the bird's MHC class IIB: New data and promising perspectives
β οΈ Host: Professor Jim Kaufman (jfk31@cam.ac.uk)
MHC-dependent sexual and natural selection; insights from ecological studies on birds
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
B lymphocyte regulation of inflammation and autoimmunity
β οΈ Host: Chris Rudd, cer51@cam.ac.uk
Specificity and function of NK cells: interplay between HLA class I and KIR gene polymorphism
β οΈ Host: Ashley Moffett (am485@cam.ac.uk)
The GIMAP/IAN GTPases, regulators of lymphocyte development and survival
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
CD4 T cells during Schistosome infection-limiting liver pathology at the cost of obstructing immunity
β οΈ Host: Anne Cooke, ac@mole.bio.cam.ac.uk
Intracellular Immunity: virus neutralisation inside infected cells
β οΈ Host: John Trowsdale, jt233@cam.ac.uk
Dispersive Salmonella infections: a hit and run strategy
β οΈ Host: Adrian Kelly (apk23@cam.ac.uk)
Molecular organization and signaling at the T-cell surface: system-level and single molecule-based analysis
β οΈ Host: Jim Kaufman, jfk31@cam.ac.uk
Marek's disease virus latency and reactivation: the role of telomeres in integration and mobilization of viral DNA
β οΈ Hosts: Truus Abbink, gema2@cam.ac.uk & Jim Kaufman, jfk31@cam.ac.uk
Marek's disease: an excellent natural model for herpesvirus evolution, vaccines, microRNAs and cancer
β οΈ Hosts: Jim Kaufman jfk31@cam.ac.uk & Truus Abbink gema2@cam.ac.uk
The immune system in pregnancy
β οΈ Host: Jim Kaufman jfk31@cam.ac.uk
The role of drift and selection in shaping worldwide MHC sequence diversity
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Understanding T cell differentiation through transgenic and semantic analysis of transcriptomes
β οΈ Host: Nick Holmes (nh106:cam.ac.uk)
Skin inflammation from genes to function and therapy
β οΈ Host: Helga Schneider (hs383@cam.ac.uk)
Evolution of quality control strategies in self/non-self discrimination systems
β οΈ EXTRA TALK; Host: Jim Kaufman (jfk31@cam.ac.uk)
Evolution of thymopoiesis in vertebrates
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
NKG2D in NK cell physiology: Two sides of the same player
β οΈ Host: Francesco Colucci (fc287@medschl.cam.ac.uk)
Structural defects of the primary and secondary lymphoid organs in the ageing immune system
β οΈ Host: Adrian Kelly (apk23@cam.ac.uk)
The IFN system in avian influenza infection in chickens
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Collagen-binding immune receptors: Form and Function
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
Bridging innate and adaptive immune responses to optimize vaccination strategies
β οΈ Host: Adrian Kelly (apk23@cam.ac.uk)
Development of synthetic glycolipid agonists for iNKT cell mediated protection from type 1 diabetes
β οΈ THIS TALK WILL HAPPEN AS SCHEDULED BUT WITH HOST JIM KAUFMAN (JFK31@CAM.AC.UK) DUE TO ASH CLOUD Host: Anne Cooke (ac@mole.bio.cam.ac.uk)
Integration of herpesvirus DNA into host chromosomes - where, when and why
β οΈ THIS TALK IS POSTPONED DUE TO ASH CLOUD Hosts: Jim Kaufman (jfk31@cam.ac.uk) & Truus Abbink (gema2@cam.ac.uk)
Maintenance of T helper cell memory
β οΈ Host: Nick Holmes (nh106@cam.ac.uk)
Controlling secretion at the immunological synapse
β οΈ Host: Nick Holmes (nh106@cam.ac.uk)
Evolution and involution of CD4 memory
β οΈ Host: Nick Holmes (nh106@cam.ac.uk)
The role of natural killer cells in MS
β οΈ Host: John Trowsdale (jt233@cam.ac.uk); SPONSORED BY Cambridge Research Biochemicals
Imaging T cell activation and functional diversification in vivo
β οΈ Host: Helga Schneider (hs383@cam.ac.uk)
How inhibition leads to activation - the dynamics of natural killer cell education
β οΈ Host: Francesco Colucci (francesco.colucci@bbsrc.ac.uk)
The role of NK cells and their receptors in cancer and transplantation
β οΈ Host: Ashley Moffett (am485@cam.ac.uk)
Human T cell immunity against tumour antigens
β οΈ Host: Peter Goon (pg336@cam.ac.uk)
T cell responses to EBV: viral evasion, antigen immunodominance and priming
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
New insights into T cell antigen receptor signalling
β οΈ Host: Chris Rudd (cer51@cam.ac.uk)
Immunity and immunopathology in an experimental malaria infection
β οΈ Host: Anne Cooke (ac@mole.bio.cam.ac.uk)
Temporal and spatial regulation of cell surface proteinase, MT1-MMP: an essential mechanism for cellular invasion
β οΈ Host: Helga Schneider (hs383@cam.ac.uk)
HIV microbicides: current and emerging candidates
β οΈ Host: Chris Rudd (cer51@cam.ac.uk)
Adaptive variation and evolutionarily conserved MHC-DRB supertype-binding motifs in Old World primates
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Regulation of airway remodelling in asthma
β οΈ Host: Andrew Wyllie
Haplotype-specific transcription in the human MHC and susceptibility to autoimmune disease
β οΈ Host: John Trowsdale (jt233@cam.ac.uk); sponsored by Gen-Probe
miRNA-155 regulates immune responses
β οΈ Host: Anne Cooke (ac@mole.bio.cam.ac.uk)
Reverse Phenotyping: towards an integrated (epi)genomic approach to common disease and complex phenotypes
β οΈ Host: John Trowsdale (jt233@hermes.cam.ac.uk)
Additional layers of complexity in the KIR:MHC systems
β οΈ Host: Ashley Moffet (am485@cam.ac.uk)
Population genetic puzzles of the MHC
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
HPV vaccines β will they do their job?
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Lymphoid tales: TNFAIP8 in glucocorticoid killing β E4BP4 and the origin of NK cells
β οΈ Host: Ashley Moffet (am485@cam.ac.uk)
A journey through parasite genetics in search of protective antigens
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Human NK Cell Receptor Diversity Shaped by Natural Selection
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
CD22 and Siglec-G: Two inhibitory receptors on B cells with distinct functions
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
Notch and peripheral immunity
β οΈ Host: Chris Rudd (cer51@hermes.cam.ac.uk)
The global circulation of seasonal influenza viruses
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Regulatory T cells inhibit antigen-dependent T cell function but not bystander T cell activity: implications for pathogenesis of RA
β οΈ Host: Helga Schneider (hs383@cam.ac.uk)
Why does HLA-B27 predispose to autoimmune Spondyloarthritis?
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
Alternatively activated macrophages in helminth infection: a paradigm for Th2 immunity
β οΈ Host: Anne Cooke (ac@mole.bio.cam.ac.uk)
Tolerogenic dendritic cells in chronic helminth infection
β οΈ Host: Nick Holmes (nh106@cam.ac.uk)
Using natural epitopes to uncover disease mechanisms in autoimmune diabetes
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
Families of IgSF receptors
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Spatio-temporal regulation of signalling during phagocytic uptake
β οΈ Helga Schneider (hs383@hermes.cam.ac.uk)
Next Generation DNA Sequencing with the Illumina Genome Analyser: Application to bacterial and human genome sequencing and transcriptome analysis
β οΈ Host: Jim Kaufman (jfk31@cam.ac.uk)
Immune regulation in granulomatous inflammation: lessons from Leishmania
β οΈ Host: Anne Cooke (ac@mole.bio.cam.ac.uk)
Pathways controlling tolerance to pancreas-expressed antigens
β οΈ Host: Chris Rudd (cer51@hermes.cam.ac.uk)
The Influence of the HLA and KIR loci in HIV disease
β οΈ EXTRA TALK! Host: Prof. Ashley Moffet (am485@cam.ac.uk)
Gamma-herpesvirus neutralization: why, when and how
β οΈ Host: Nick Holmes (nh106@cam.ac.uk)
Role of oligomeric assemblies in signal transduction and crosstalk by the TLRs
β οΈ Host: Adrian Kelly (apk23@cam.ac.uk)
Transplantation tolerance: are we getting closer?
β οΈ Host: John Trowsdale (jt233@cam.ac.uk)
Development and function of mucosal NK cells: lymphoid tissue inducer-like cells or NK-22
β οΈ Host: Ashley Moffett (am485@hermes.cam.ac.uk)
A role for Th17 in the development of Type 1 diabetes?
β οΈ host: Jim Kaufman (jfk31@cam.ac.uk)
Decoding the antigen-specific T cell repertoire: immune selection and biological outcome
β οΈ Host: Dr. Nick Holmes (nh106@cam.ac.uk)
The balance between Th17 and Treg cells - influence of infection and implications for autoimmunity
β οΈ Host: Professor Anne Cooke (ac@mole.bio.cam.ac.uk)
Cancer immunotherapy with gene modified T cells
β οΈ Host: Prof. John Trowsdale (jt233@cam.ac.uk)
The mechanisms and dynamics of HTLV-1 persistence and spread
β οΈ Host: Dr. Peter Goon (pg336@cam.ac.uk)
The effect of PECAM-1 gene polymorphism on adhesion and transmigration of leukocytes across endothelium
β οΈ Host: Dr. Mike Clark (mrc7@cam.ac.uk)
The immune response to HBV: control versus pathogenicity
β οΈ Host: Dr. Helga Schneider (hs383@hermes.cam.ac.uk)
Molecules mediating the surveillance of body surfaces by local T cells
β οΈ Host: Prof Jim Kaufman (jfk31@cam.ac.uk)
Understanding the role of HLA-B27 in inflammatory arthritis
β οΈ Host: Prof. John Trowsdale (jt233@cam.ac.uk)
CTLA-4 modulation of T-cell anergy and motility
β οΈ Host: Prof. Jim Kaufman (jfk31@cam.ac.uk)
Please see above for contact details for this list.