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Professor Eric Westhof (Institut de Biologie MolΓ©culaire et Cellulaire du CNRS, UniversitΓ© de Strasbourg).
Wednesday 20 February 2019, 16:00-18:00
Structural Biology at Biochemistry
Description to be confirmed
Contact: Marko Hyvonen ; Katherine Stott
0 upcoming talks View 556 archived talks
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
tRNA Modifications and Decoding Errors
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
A Saposin-lipoprotein nanoparticle system for membrane proteins
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Capturing the 3D Folds of Whole Mammalian Genomes in Single Cells
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Protein:protein recognition in the Ubiquitin Proteasome-degradation System (UPS) and Membrane Surface Complexes from the Ras-family
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Structural studies of a DNA unwinding machine
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Architecture of PIKK Kinases and their molecular mechanisms of regulation
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Protein and Peptide Mass Spectrometry Analysis
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Solution-based angular measurements of protein structure and conformational change by second-harmonic generation (SHG)
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Fragment based inhibition of CK2Ξ±
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Correlative tweezers fluorescence microscopy: one step towards real-time single-molecule biology
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Substrate reduction enabled by structural biology as therapy for metabolic disorders
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Toward the Reconstitution of the Maturation of Okazaki Fragments Multiprotein Complex in Human at the Single Molecule Level
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Using Computational Structure Biology to Study Diseases that cause Major Health Concerns in Brazil
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Not Too Big - Not Too Small: Fragment Antibody Drug Candidates as Alternatives to Antibodies for Solid Tumours
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Mycobacterium Tuberculosis Physiology: The Intricate Interplay between Drug Tolerance and Drug Resistance
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Shortening Tuberculosis Chemotherapies: Elucidating the Molecular genetic programs of persistence of M. tuberculosis
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Human 2-oxoacid-dependent Oxygenases
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
The simple reason that M. avium subspecies paratuberculosis has been missed as a major human pathogen is that, unknowingly, it's been treated since 1942
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Signalling through interleukin/interferon receptors: outside and inside of the cell
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Linking Structural Biology and Clinical Genomics: Purine Nucleotidase in Relapsed Leukemia
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Revolutionary Cryo-EM: the Potential Power to Visualize High Resolution Dynamic Structures
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Rebuilding the HDX-MS Method to Support Integrative Methods in Structural Biology
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
High-Throughput Fragment-Based Drug Discovery at Diamond Synchrotron: Robots can do much of the work to screen in FBDD!
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
COSMIC Catalogue of Cancer Mutations and the 3D Proteome
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Dynamic interactions and fuzzy structures in protein complexes and higher-order assemblies
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Using Integrative Methods in Structural Biology to Understand Protein Structure
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Computational study of mutations in proteins
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Myc and MexR: conformational selection and fuzzy complexes in transcriptional regulation
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
What's new at PDBe?
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Phosphoproteomic strategies reveal global impact of kinase inhibitors on regulatory kinase networks and the phosphoproteome
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
A computational framework for optimizing combination drug therapies
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Structure and Function of TIFA - A New Player in Immunity and Cancer
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Interactive molecular dynamics for improved model building and exploration in structural biology
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Predicting the impact of natural and disease variants on protein function
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Targeting Trehalose and Methylglucose Lipopolysaccharide Pathways of M. tuberculosis
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
TBC
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Matching density maps of macromolecular assemblies from Cryo-EM and assessment of fitted atomic models
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
The 3D structures of genomes in single cells reveal principles of nuclear organization
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
The E. coli replisome caught in the act by cryo-EM and single molecule microscopy
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Pregnancy outcome prediction using placenta epigenetic data
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Protein transport to the endoplasmic reticulum
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Computational approaches to investigate protein-nucleic acid and protein-protein interactions
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Mapping of ligand binding site and activation mechanism of APJ receptor
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Dr Paul Brear - Inhibiting CK2Ξ± from outside the active site
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Prof Song Tan - TBC
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Fitting atomic structures into EM density maps
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Migle Kisonaite - "Structure of Gremlin-1: Insights into the Mechanism of Bone Morphogenetic Protein Antagonism" and Xuelu Wang "Understanding of the Pro-domain in TGF-Ξ² Superfamily: Structure and Characterisation of Pro-activin A"
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
ARCIMBOLDO, an ab initio approach to MR phasing
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Atomic resolution cryoEM structure of bacteriophage
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Modulating Protein-Protein Interactions
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Title to be confirmed
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Structural Biology and Transmembrane Signalling: Understanding a 'Double-edged' Receptor, DCC
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Impact of rapid whole-genome sequencing on diagnostic and public health microbiology
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Structural Mechanisms in Protein Kinase Regulation
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Predicting drug-target binding kinetics through enhanced sampling simulations
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Biodiversity and Drug Discovery
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Recent advances in high resolution cryo-EM structure determination
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Dr Meindert Lamers - Title to be confirmed
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Dr Isaac Westwood - Title to be Confirmed
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Dr Christian Ottmann, Title to be confirmed
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Investigating the human proteasome by cryo-EM - an emerging tool for structural based drug design
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Dr Takashi Ochi and Dr Qian Wu
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Tools for refinement against low resolution X-ray data and fit to EM reconstructions
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Identification and characterization of interaction sites with MD simulations of mixed solvents β Application to non-standard targets
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
(1) An introduction to Gene Synthesis - capabilities and uses. (2) An introduction to precise genome editing with TAL effectors and CRISPR
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Support Science and Diamond Light Source
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Professor Randy Read - title to be comfirmed
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Structures and mechanisms of macromolecular complexes involved in transcription and DNA repair
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Crystal structure of the Drosophila Toll-SpΓ€tzle complex reveals neurotrophin-like binding specificity
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
How insulin binds to the insulin receptor: structural biology and protein engineering
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
The Structure of the Large Subunit of the Yeast Mitochondrial Ribosome
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Coot's EM Model-fitting Tools
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Small Angle X-ray Scattering: sample preparation, data collection, and data analysis.
Structural Biology group talks at Biochemistry
The extracellular lysine residues of in vitro folded neuropeptide receptor type 2 interacting with its ligand observed by > NMR spectroscopy
Structural Biology group talks at Biochemistry
Targeting Ubiquitin chains with Deubiquitinases
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Cyclofluidic: Quick hit-to-lead optimization using an integrated microfluidic approach
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Title to be confirmed
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Using evolutionary sequence variation to make inferences about protein structure and function
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Protein-Protein Interaction Networks and Diseases
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Analysis of allosteric communication and functional local motions using a Structural Alphabe
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Chirality as a crossroad of chemistry and biology
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Title to be confirmed
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Evolution & dynamics of protein complexes
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Crystallisation and structure of respiratory complex I, a giant molecular proton pump
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Probing dynamic conformational changes in lipid signalling using hydrogen deuterium exchangemass spectrometry
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Open Source Drug Discovery:Β Developing a Systems LevelΒ Translational Platform for Neglected Diseases
Structural Biology group talks at Biochemistry
Come and meet the Monster: a work in progress on human Rad51 oligomeric structure ("the Monster") and its potential relevance for DNA Repair and drug design.
Structural Biology group talks at Biochemistry
Single molecule imaging reveals that CENP-A deposition occurs during G2 in fission yeast
Structural Biology group talks at Biochemistry
New Developments at Diamond Light Source and the use of Free Electron Lasers in structural biology
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
PHASER workshop
Structural Biology group talks at Biochemistry
Assembly of a protein-RNA bacterial suicide complex
Structural Biology group talks at Biochemistry
Mechanisms of extracellular regulation of TGFΞ² superfamily: protein engineering and interaction analysis
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
OPPF-UK: a national resource centre for protein production.
Structural Biology group talks at Biochemistry
Snaphshots of Membrane Proteins at Work
Structural Biology group talks at Biochemistry
The role of the acidic tail in HMGB proteins: a combined NMR and SAXS approach
Structural Biology group talks at Biochemistry
Specificity in the Ubiquitin System
Structural Biology group talks at Biochemistry
Dissecting Fragment-Based Lead Discovery at the von Hippel Lindau protein:Hypoxia Inducible Factor-1alpha Interface
Structural Biology group talks at Biochemistry
The Discovery of Novel Sialidase Inhibitors
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
AnchorQuery: Interactive and efficient discovery tool of small molecule protein-protein interaction antagonists
Structural Biology group talks at Biochemistry
Catalytic Promiscuity in the Alkaline Phosphatase Superfamily
Structural Biology group talks at Biochemistry
Label-free Study of Chromatin Architecture in Living Organisms using Stimulated Raman Scattering Microscopy
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Identifying hot-spots and designing small molecule inhibitors at protein-protein interfaces: taking advantage of bound water networks
Structural Biology group talks at Biochemistry
Replication Initiation: Focus on the Components of the Pre-initiation Complex
Structural Biology group talks at Biochemistry
The Structural Basis of Z Alpha-1-antitrypsin Deficiency
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
The importance of thermostability and its application to the structure determination of GPCRs
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
X-ray diffraction data reduction: space group determination, scaling and intensity statistics
Structural Biology group talks at Biochemistry
PHD Zinc Fingers in Chromatin-Associated Proteins
Structural Biology group talks at Biochemistry
NMR Applications to Large Systems: Sensory Rhodopsin II, Membrane Mimics and Fast NMR
Structural Biology group talks at Biochemistry
The Structures of Whole Chromosomes in Individual Cells
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Title to be confirmed
Structural Biology group talks at Biochemistry
Crystal Structure of Folliculin Uncovers a HiDENN Function
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Structural studies of chromosome segregation
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
SAXS studies on biological molecules at Diamond Light Source
Structural Biology group talks at Biochemistry
Structural studies of HAT1 and its binding partners
Structural Biology group talks at Biochemistry
Allosteric Regulation and Assembly of Glutamate Receptor Ion Channels.
Structural Biology group talks at Biochemistry
David Lando Talk
Structural Biology group talks at Biochemistry
From protein interactions to gene expression distributions
Structural Biology group talks at Biochemistry
Solid-State NMR Investigations of Membrane Bound Ras Proteins and Y2 G Protein-Coupled Receptors
Structural Biology group talks at Biochemistry
Structural Biology facilities - Updates and Discussion Session
Structural Biology group talks at Biochemistry
A Study of the Human Primase: Initiator of DNA Replication
Structural Biology group talks at Biochemistry
Relating structure to function in natural surfactant proteins.
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Domain swapping in proteins
Journal Clubs
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
To be confirmed
Structural Biology group talks at Biochemistry
FKBP - a structure without a cause?
Structural Biology group talks at Biochemistry
Model interaction systems in the search for inhibitors of protein-protein interactions
Research seminars
Group meeting
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Low Resolution Crystallography
Structural Biology group talks at Biochemistry
Zinc fingers reading signals
Research seminars
Research seminar
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Making candy for signal transduction research - Adventures in Willy Wonka land
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Low resolution refinement tools in the program REFMAC
Research seminars
Research seminar
Research seminars
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Fuzzy complexes: ambiguity in protein-protein and protein-DNA interactions
Structural Biology group talks at Biochemistry
A Bayesian view on cryo-EM structure determination
Journal Clubs
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Research seminar
Structural Biology group talks at Biochemistry
Structural and interaction studies of domain C0 of cardiac Myosin Binding Protein C (cMyBP-C) by NMR spectroscopy
Structural Biology group talks at Biochemistry
At the Frontier of Membrane Protein Crystallography: The Structure of Yeast Aquaporin to 0.9 Γ at Cryogenic and 1.3 Γ at Room Temperature.
Research seminars
Research seminar
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Research seminar
Structural Biology group talks at Biochemistry
Most recent development in crystalisation optimization and shotgun diffraction
Structural Biology group talks at Biochemistry
Snapshots of the membrane protein Mhp1 at work
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Structural complexomics of eukaryotic gene expression.
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Receptor-based Drug Discovery
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Probing protein-ligand recognition mechanisms with isothermal titration calorimetry
Structural Biology group talks at Biochemistry
"Structural Basis of the Regulation of Chromosome Segregation and Mitosis Progression"
Structural Biology group talks at Biochemistry
"A new structural genomics: the structures of whole chromosomes"
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Crystal dehydration: Experimental design with a home source and at the synchroton
Structural Biology group talks at Biochemistry
"Structure of a motor-driven restriction-modification enzyme bound to its target DNA"
Structural Biology group talks at Biochemistry
"Structure-function studies of the archaeal HR nuclease NurA"
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Designing Bioactive Molecules and Mode-of-Action Analyses - The Benefits of Learning From the Past.
Structural Biology group talks at Biochemistry
Determining structures with NMR - the CcpNmr Analysis program
Structural Biology group talks at Biochemistry
"DNA Polymerase alpha at work: Understanding the Mechanism"
Structural Biology group talks at Biochemistry
"Chromatin Assembly Factor 1: Working with protein complexes"
Structural Biology group talks at Biochemistry
"Structural studies of non-coding RNA mediated gene silencing in E. coli"
Structural Biology group talks at Biochemistry
"Mimicking the membrane; micelles, bicelles and nanodiscs"
Structural Biology group talks at Biochemistry
"Do very similar proteins fold in very similar ways?"
Structural Biology group talks at Biochemistry
"Using high throughput simulation to understand signalling processes"
Structural Biology group talks at Biochemistry
"Structure of RLIP76βs GTPase activating (GAP) and Ral binding domains (RBD) in solution"
Research seminars
Group meeting
Structural Biology group talks at Biochemistry
"Super-resolution imaging in pombe"
Structural Biology group talks at Biochemistry
"Structural studies of a human non-homologous end-joing protein complex: DNA ligaseIV/XRCC4"
Research seminars
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Journal Clubs
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Structural Biology group talks at Biochemistry
"Segmental labelling approaches for multi-domain proteins"
Structural Biology group talks at Biochemistry
"New dimensions in the study of protein complexes using mass spectrometry"
Research seminars
Research seminar
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Structural Biology group talks at Biochemistry
"The structural studies of PHD+CXXC domain"
Structural Biology group talks at Biochemistry
"Fragment-based drug discovery on the MET receptor"
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Research Seminars - Department of Biochemistry
Protein dynamics illuminated by studies of bacterial behaviour
Research seminars
Group meeting
Structural Biology group talks at Biochemistry
Super-resolution imaging in pombe
Structural Biology group talks at Biochemistry
"Structural Studies Of Innate Immune Response"
Journal Clubs
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Journal Club
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Drug Protein Interaction Databases
Research seminars
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Research seminar
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
The Ghosts of PDBe Past, Present Β and Yet to Come
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
i-SITE: An energetic approach to predict ligand-binding site on protein surface
Structural Biology group talks at Biochemistry
Modular Protein Architecture, Cooperativity and Complexity in Cell Regulation
Research seminars
Group Meeting
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Protein crystallisation seminars
Ways and means: home brewed microdialysis methods
Research seminars
Group Meeting
Research seminars
Group Meeting
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
The rational design of small-molecule Neuropilin-1 antagonists
Research seminars
Research seminar
Research seminars
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Restraints on Protein Models from NMR Chemical Shifts
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Software for fragment linking and growing.
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Using Biacore for fragment screening
Structural Biology group talks at Biochemistry
Molecular recognition of chromatin: crystal structure of the chromatin factor RCC1 in complex with the nucleosome core particle
Research seminars
Research seminar
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Off-site Targets: Predicting drug polypharmacology using ligand similarity ensembles.
Research seminars
Research seminar
Research seminars
Research seminar
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Targetting Protein-Protein Interactions: Synergies between NCEs and New Antibodies.
Structural Biology group talks at Biochemistry
TICed off with protein transport into Plasmodium apicoplasts
Structural Biology group talks at Biochemistry
Targeting tuberculosis: fragment-based approaces to drug discovery
Journal Clubs
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Research seminars
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Fragment-based drug discovery using X-ray crystallography.
Structural Biology group talks at Biochemistry
RNA processing machinery
Structural Biology group talks at Biochemistry
Computational Structural Biology in a Pharma
Research seminars
Research seminar
Research seminars
Research seminar
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Can machines understand the Scientific Literature?
Structural Biology group talks at Biochemistry
Chaperoning histones - structural studies of the H3/H4/RbAp48 complex.
Structural Biology group talks at Biochemistry
StructuralΒ and evolutionary relationship among epoxide hydrolase in ionophores producing streptomyces
Journal Clubs
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY
Research seminars
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Structural Biology group talks at Biochemistry
Solving membrane protein's structure for dummies
Research seminars
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Structural Biology group talks at Biochemistry
Structural and functional analysis of the interaction between ICAM-1 and DBL domains implicated in cerebral malaria
Structural Biology group talks at Biochemistry
Structural basis for the association of a chromatin remodelling complex with a transcriptional coregulator
Research seminars
Group Meeting
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Structural Biology group talks at Biochemistry
Dissecting the affinity and specificity of ligand for a bipartite ATP-binding site: Structure of the Ligand-bound Pyrococcus furiosus RadA
Structural Biology group talks at Biochemistry
Fun with Coiled-coils - the interaction of HR1 domains with Rho family proteins
Research seminars
Research Seminar
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Research Seminar
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Engineering proteins for fragment screening
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Surface Plasmon Resonance
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
STING_DB
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Drug-protein Databases: ZINC, Credo,Β CHEMBL
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Research Seminar
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Research Seminar
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Fragments versus traditional screening . Off-targetΒ analysis
Research seminars
Research Seminar
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
ITC
Research seminars
Group Meeting
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
X-ray single soaks or cocktails? GrowingΒ versus Linking.Β
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Targetting PPI
Research seminars
Research Seminar
Research seminars
Research Seminar
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Recap of Experimental Fragment-based projects
Structural Biology group talks at Biochemistry
Mechanism of initiation of DNA synthesis in eukaryotic replication
Structural Biology group talks at Biochemistry
Thaimine enzyme structure and mechanism
Structural Biology group talks at Biochemistry
Title to be confirmed
Structural Biology group talks at Biochemistry
Title to be confirmed
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Research Seminar
Structural Biology group talks at Biochemistry
Molecular characterisation of human CtIP, a DNA-end resection protein
Structural Biology group talks at Biochemistry
Custom designing E. coli genomic mutations
Research seminars
Research Seminar
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Research seminars
Group Meeting
Structural Biology group talks at Biochemistry
Structure and function of PfEMP1; the sticky protein from Plasmodium falciparum
Structural Biology group talks at Biochemistry
Title to be confirmed
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Completely in vitro protein engineering automation
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Research Seminar
Structural Biology group talks at Biochemistry
Title to be confirmed
Structural Biology group talks at Biochemistry
Crystal diffraction quality: The secret lies in the soak!
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Research Seminar
Structural Biology group talks at Biochemistry
CARD tricks - magic or mutant?
Structural Biology group talks at Biochemistry
Homo- & Hetero-Dimerisation of TGF-beta superfamily proteins
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Research Seminar
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Molecular recognition - from single target to protein complexes
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Wetlab meeting
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
HIV-1 Reverse Transcriptase: Structure, Drug Resistance, and Drug Design
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
The microseed matrix screening method for protein crystallisation
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Group meeting
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Group meeting
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Electrochemically-assisted protein crystallisation: Applications to biosensors
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Public domain medicinal chemistry data at the EBI and the use in drug discovery
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Research Seminar
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
The influence of electric and magnetic fields to increase the crystal quality of proteins
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
The role of impurities in protein crystallisation: advantages and disadvantages
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Research Seminar
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Protein Crystal Growth in Gels and Capillary Tubes
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Group meeting
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Conventional and non-conventional methods of protein crystal growth
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Cheminformatics practical session
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Recent adventures in protein folding and design
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Leaving drinks for Sheena
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
SPR - theory and practise
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Biocore
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Group Meeting
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Research Seminar
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Research Seminar
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Expression systems for protein complexes
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Pathway-based analysis of genome-wide siRNA screens
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Research Seminar
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Research Seminar
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Party for Richard and Timo
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Research Seminar
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Research Seminar
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Fragment-based Screening and It's Role in Ontario Cancer Institute
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Molecular Puzzles: Learning About Function and Mechanism of Enzymes From their Structures
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Convergence of Molecular Epidemiology, Functional Biology and Host-pathogen Interactions: Zeroing on Potential Drug Targets for M. TUBERCULOSIS
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Group Meeting - Cancelled
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Research Seminar - Cancelled
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Research Seminar
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
test
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Neurotrophic factors in Drosophila
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Small hydrogen-bonded motifs in proteins and their significance for amyloid formation
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Group meeting
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Structural chemistry in the pharmaceutical industry: view from a returned exile
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
DNA site-specific recombination: Architecture of a recombinase
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Mechanisms of Transmembrane Transport: towards structures of membrane protein drug targets
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Toll like receptors - Investigating innate immunity and infection
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Group meeting
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
High intrinsic binding specificity mediates the interactions of a yeast SH3 domain
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Expriences in Structure-based Discovery
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Title to be confirmed
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Group meeting
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Fragment based drug discovery - from crystal to clinic
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Paradoxical Features of Nicotinic Receptor
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
New protein purification columns and media from GE Healthcare
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
UCB Approaches to Drug Discovery, A Focus on 2 Cambridge projects
Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
Structural basis of fatty acid synthesis catalyzed by giant multienzyme complexes
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Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery
The long and the short: virulence proteins from Staphylococcus and Streptococcus
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